Detecting and Treating Endometrial Cancer
PCOS and Endometrial Cancer Risk
Polycystic ovarian syndrome leads to excess estrogen production, which has been linked to increased endometrial cancer risk.
By Diana Rodriguez
Medically Reviewed by Lindsey Marcellin, MD, MPH
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Endometrial cancer is the form of uterine cancer that's most commonly diagnosed. Women can be at higher risk for endometrial cancer for several reasons, including health conditions and lifestyle factors that can boost their estrogen levels. Polycystic ovarian syndrome, or PCOS, is one of those health conditions known to increase a woman’s chances of developing endometrial cancer.
Ovaries produce the hormone estrogen and the egg that is released monthly — a process called ovulation — during a woman's reproductive years. PCOS is a condition of the female reproductive system that causes a bunch of small cysts, which are tiny sacs of fluid, to form on the ovaries. Women with PCOS typically don't ovulate and have abnormally high levels of androgen hormones, often called "male" hormones.
Women with PCOS also have increased levels of estrogen and abnormally low levels of progesterone, another hormone.
The Estrogen Factor
Hormone levels play a big role when it comes to cancer risk — particularly types of uterine cancer like endometrial cancer. Women with PCOS and other factors that increase estrogen levels — including obesity, diabetes, or taking medications like tamoxifen (Nolvadex, Tamosin, Tamofen, Tamoxen) or estrogen replacement therapy — are more likely to develop endometrial cancer than those without these factors. The abnormal amounts of estrogen are particularly risky when not balanced by sufficient progesterone levels in the blood. This is why post-menopausal women who have not had a hysterectomy and who need treatment for severe menopausal symptoms will be prescribed both estrogen and progesterone, instead of estrogen alone.
Progesterone is the hormone responsible for the monthly "shedding" process of the endometrium — or the lining of the uterus. This process results in monthly menstruation, which many women with PCOS don't have because of insufficient progesterone levels. Without progesterone and monthly periods, the endometrium becomes thick and the cells may become altered, leading to a precancerous condition called endometrial hyperplasia. Eventually, endometrial cancer may develop if PCOS is left untreated.
Reducing Your Endometrial Cancer Risk
While you can't prevent PCOS, it's important to know your risk for endometrial cancer and figure out what you can do to protect your health and minimize that risk.
If you have PCOS, do what you can to keep other risk factors for endometrial cancer in check:
- Treat your PCOS.If left untreated, hormone levels will remain abnormal and affect your whole body and your cancer risk. Seek treatment for PCOS early and regulate hormone levels. You can do this with oral contraceptives — progesterone-only pills are best to reduce endometrial cancer risk — or metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet), the diabetes medication, to manage hormone production. Surgery may also be an option.
- Reach and maintain a healthy body weight.Most often, women with PCOS are obese or overweight. And obesity is a known risk factor for endometrial cancer because it also increases estrogen levels. By getting regular exercise and sticking to a healthy diet, you can lose excess pounds and minimize your endometrial cancer risk, even if you have PCOS.
- Avoid fat in your diet.Besides helping avoid unwanted pounds, trimming the fat from your diet can reduce endometrial cancer risk. It's thought that fat affects the way that estrogen is metabolized and used by the body, which can also raise the chances of developing endometrial cancer.
- Get regular Pap smears and pelvic exams.If you already know you're at a greater risk for endometrial cancer because of your PCOS, it's important to keep an eye out for early signs of cancer. Having a regular pelvic exam done by your gynecologist can help to identify endometrial cancer and begin treatment.
Having PCOS doesn't mean you're destined to develop endometrial cancer, but it does mean that you're at an increased risk for the disease. So take good care of yourself by focusing on preventive care, maintaining a fit body, and living a healthy lifestyle to reduce your endometrial cancer risk.
Video: Risk Factors Of Polycystic Ovarian Syndrome - Manipal Hospital
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